His film credits include roles in X-Men Origins: Wolverine, Steal This Movie! (where he portrayed activist Bobby Seale), the indie comedy Fizzy Bizness, and the supernatural thriller The Invisible. On television, Panou has appeared in a variety of popular series such as Caprica, I Was A Sixth Grade Alien, Stargate SG-1, and Stargate Atlantis, often portraying compelling supporting characters across genres. His career reflects a consistent presence in science fiction and dramatic storytelling within the North American entertainment industry.